circRNA basic information
circBase ID: hsa_circ_0070269
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr4:84015830-84029103:-
Genomic location(hg38): chr4:83094677-83107950:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood / whole blood / peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NPTX1
Associated microRNA: miR‐182
Biological function: Tumor suppressor; inhibits cell growth and invasion; sponges miR-182 and increases NPTX1 expression in the context of HCV-induced HCC.
Molecular mechanism: ceRNA/miRNA sponge mechanism: hsa_circ_0070269 sponges miR-182 to derepress NPTX1.
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Suggested as diagnostic biomarker and therapeutic target for HCV induced HCC.
Description:

In HCV-induced HCC patient blood, hsa_circ_0070269 is significantly down-regulated. The study supports a tumor-suppressive ceRNA role where hsa_circ_0070269 sponges miR-182, relieving repression of NPTX1, and proposes it as a diagnostic biomarker/therapeutic target.
Confidence score:

0.348
Other information
Title:

Bioinformatics and Experimental Insights Into miR-182, hsa_circ_0070269, and circ-102,166 as Therapeutic Targets for HCV-Associated HCC.

Journal: Cancer reports (Hoboken, N.J.)
Published: 2024
PubMed ID: 39617640
Study type:

combined biological and clinical study
Data availability: GSE121714; GSE155949; GSE40744; GSE108724; GSE136247; GSE25097
Code availability: -