| Expression pattern: |
UP |
| Associated gene: |
MMP2, MMP9 |
| Associated microRNA: |
miR-665 |
| Biological function: |
circSFMBT2 promotes gastric cancer cell viability, migration, invasion and glutamine decomposition, and inhibits apoptosis in the paeonol-treated HGC-27 cell context. |
| Molecular mechanism: |
circSFMBT2 acts through the circSFMBT2/miR-665 axis and negatively regulates miR-665; paeonol down-regulates circSFMBT2 and thereby affects proliferation, apoptosis, migration, invasion and glutamine decomposition in gastric cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circSFMBT2 is up-regulated in gastric cancer tissues and HGC-27 cells. In paeonol-treated gastric cancer cells, circSFMBT2 overexpression counteracts paeonol-induced suppression of proliferation, migration, invasion and glutamine decomposition and reduces apoptosis, at least partly through negative regulation of miR-665. |
| Confidence score: |
0.8263 |