circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: MTO1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast tissues; adjacent normal tissues
Cell lines:

MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic potential for discriminating breast cancer from normal tissues and distinguishing disease stages/progression.
Description:

circMTO1 is down-regulated in breast cancer tissues compared with adjacent normal tissues and can be quantified by the proposed CRISPR nanoswitch. Its measurement contributes to diagnostic discrimination and staging/progression classification (especially when combined with circCDYL).
Confidence score:

0.559
Other information
Title:

Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer.

Journal: Nucleic acids research
Published: 2025
PubMed ID: 41206041
Study type:

combined biological and clinical study
Data availability: Data will be made available on request.
Code availability: -