circRNA basic information
circBase ID: hsa_circ_0003537
Name: hsa_circ_KIAA1797
Synonym: circKIAA1797
Host Gene: KIAA1797
Genomic location(hg19): chr9:20907148-20916936:+
Genomic location(hg38): chr9:20907149-20916937:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; paired nontumor tissues; serum; serum exosomes; xenograft tumor tissues
Cell lines:

N87; HGC27; AGS; MKN-45; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PBX3, Ago2, Bcl-2, Bax
Associated microRNA: miR-4429
Biological function: Exosomal circKIAA1797 promotes GC cell proliferation, migration, invasion, glycolytic metabolism and tumor growth, and inhibits apoptosis.
Molecular mechanism: Exosomal circKIAA1797 acts as a ceRNA sponge for miR-4429 to up-regulate PBX3 expression, thereby promoting malignant progression and glycolysis in GC.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

High circKIAA1797 expression was associated with TNM stage and H. pylori-infection, and exosomal circKIAA1797 may be a potential therapeutic target for GC.
Description:

Exosomal circKIAA1797 is up-regulated in gastric cancer tissues, cells, and serum-derived exosomes. It promotes GC malignant phenotypes, glycolysis, and tumor growth by sponging miR-4429 and up-regulating PBX3, while its knockdown suppresses proliferation, migration, invasion, glycolytic metabolism and enhances apoptosis. The study suggests exosomal circKIAA1797 as a potential therapeutic target for GC.
Confidence score:

0.7294
Other information
Title:

Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by Targeting miR-4429/PBX3 Pathway in Gastric Cancer.

Journal: Biochemical genetics
Published: 2024
PubMed ID: 37730964
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request; supplementary material available at https://doi. org/10.1007/s10528-023-10529-z
Code availability: -