| Expression pattern: |
UP |
| Associated gene: |
DTX4, Ago2 |
| Associated microRNA: |
miR-7113-3p |
| Biological function: |
promotes PDAC cell proliferation, invasion, and migration; affects apoptosis and cell cycle; promotes in vivo tumor growth |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-7113-3p to regulate DTX4 expression (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); cell cycle (other); ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
could provide novel targets for PDAC diagnosis and treatment |
| Description: |
hsa_circ_0001829 is up-regulated in PDAC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while reducing apoptosis and altering the cell cycle. Mechanistically, it functions as a sponge for miR-7113-3p to de-repress DTX4, thereby enhancing PDAC progression, and its knockdown suppresses tumor growth in a nude-mouse xenograft model. |
| Confidence score: |
0.7899 |