| Expression pattern: |
UP |
| Associated gene: |
ZIC2, Ki-67 |
| Associated microRNA: |
miR-564 |
| Biological function: |
circDPP4 promotes prostate cancer cell proliferation, colony formation, migration, invasion, tumor growth, and docetaxel resistance, while inhibiting apoptosis; silencing circDPP4 suppresses cell progression and enhances docetaxel cytotoxicity. |
| Molecular mechanism: |
circDPP4 acts as a miR-564 sponge and regulates ZIC2 expression through a ceRNA regulatory axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); chemoresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; MTT; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
High circDPP4 expression is associated with shorter overall survival and DTX nonresponsiveness; circDPP4 is suggested as a potential biomarker and therapeutic target for PC. |
| Description: |
circDPP4 is up-regulated in prostate cancer tissues and cell lines, with high expression associated with poor overall survival and DTX nonresponsiveness. Functionally, circDPP4 promotes malignant progression and docetaxel resistance, while its knockdown inhibits proliferation, colony formation, migration, invasion, and tumor growth and promotes apoptosis and DTX cytotoxicity. Mechanistically, circDPP4 acts as a cytoplasmic ceRNA sponge for miR-564 to regulate ZIC2 expression. |
| Confidence score: |
0.849 |