| Expression pattern: |
UP |
| Associated gene: |
VEGFA, Ago2 |
| Associated microRNA: |
miR-382 |
| Biological function: |
circ_0001178 promotes HCC cell proliferation, survival, migration, invasion, cell cycle progression and xenograft tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0001178 acts through a ceRNA-like miR-382/VEGFA axis, negatively modulating miR-382 and inducing VEGFA expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0001178 is highlighted as a possible diagnostic biomarker for HCC. |
| Description: |
circ_0001178 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses HCC proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and G1 arrest. Mechanistically, circ_0001178 negatively regulates miR-382 and increases VEGFA expression through the circ_0001178/miR-382/VEGFA axis. |
| Confidence score: |
0.7756 |