| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-936 |
| Biological function: |
Associated with TNBC subtype; proposed to contribute to angiogenesis and invasive behavior, potentially via miRNA sponging. |
| Molecular mechanism: |
miRNA sponge (ceRNA) suggested; m6A hypermethylation suggested to enhance stability/translation (not directly validated). |
| Biological pathway or process: |
VEGF/VEGFR (other); angiogenesis (other); ceRNA regulation (other); invasion (other) |
| Detected method: |
M
|
| Validation methods: |
MeRIP / MeRIP-seq; Microarray; RNase R Treatment; Bioinformatics Analysis |
| Clinical significance: |
Candidate subtype-specific m6A-modified circRNA biomarker for TNBC (differential methylation vs luminal). |
| Description: |
hsa_circRNA_100719 (circDOCK1) is reported as hypermethylated and upregulated in TNBC relative to luminal subtypes. It is suggested to act as a miRNA sponge (miR-936) in angiogenesis-related contexts, linking it to VEGFA-VEGFR2 pathway regulation, but without direct functional validation in this study. |
| Confidence score: |
0.453 |