circRNA basic information
circBase ID: hsa_circ_0000181
Name: hsa_circ_TATDN3
Synonym: -
Host Gene: TATDN3
Genomic location(hg19): chr1:212977661-212981190:+
Genomic location(hg38): chr1:212804319-212807848:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

fresh gastric cancer tissues; paired adjacent non-tumorous tissues; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for gastric cancer screening; decreased expression in gastric cancer tissues and plasma is associated with clinicopathologic features.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0000181 may serve as a novel biomarker for gastric cancer diagnosis; tissue AUC was 0.756, and plasma AUC was 0.582.
Description:

This study found that hsa_circ_0000181 is significantly down-regulated in gastric cancer tissues and in plasma from gastric cancer patients. Its expression is associated with several clinicopathologic features, and ROC analyses suggest potential diagnostic value as a tissue- and plasma-based biomarker for gastric cancer.
Confidence score:

0.5261
Other information
Title:

Clinical values of circular RNA 0000181 in the screening of gastric cancer.

Journal: Journal of clinical laboratory analysis
Published: 2018
PubMed ID: 28940688
Study type:

clinical study
Data availability: GSE89143
Code availability: -