circRNA basic information
circBase ID: hsa_circ_0002805
Name: hsa_circ_ZBTB46
Synonym: circZBTB46
Host Gene: ZBTB46
Genomic location(hg19): chr20:62407030-62422143:-
Genomic location(hg38): chr20:63775677-63790790:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013209
MONDO name: metabolic dysfunction-associated steatotic liver disease
Disease details: metabolic-associated fatty liver disease / MAFLD
Disease DO ID:
 0080208
Disease MeSH ID:
 D065626
Disease NCIt ID:
 C84444
Disease ICD11 ID:
 1912806631
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissues
Cell lines:

L02; Huh7; HepG2; HEK293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: FGF1, AMPK
Associated microRNA: miRNA-326
Biological function: Alleviates hepatic lipid accumulation and intrahepatic lipid deposition in MASLD.
Molecular mechanism: Acts as a ceRNA by sponging miRNA-326 to relieve suppression of FGF1 and activate AMPK signaling.
Biological pathway or process:

AMPK (promotes); lipid metabolism (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Oil Red O Staining; ELISA; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining
Clinical significance:

Potential as a diagnostic biomarker and therapeutic target for MASLD.
Description:

circZBTB46 is down-regulated in MASLD/MASH liver tissues and in experimental steatosis models. It reduces hepatic lipid accumulation by sponging miRNA-326, restoring FGF1 expression and increasing AMPK activation (phosphorylation).
Confidence score:

0.7825
Other information
Title:

CircZBTB46 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miRNA-326/FGF1 axis.

Journal: Cell death discovery
Published: 2026
PubMed ID: 41513602
Study type:

combined biological and clinical study
Data availability: All data information used and/or analyzed during the current study is available from the corresponding author upon reasonable request.
Code availability: -