circRNA basic information
circBase ID: hsa_circ_0087378
Name: -
Synonym: circ_0087378
Host Gene: -
Genomic location(hg19): chr9:87356806-87367000:+
Genomic location(hg38): chr9:84741891-84752085:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

16HBE; A549; NCI-H1299; NCI-H1975; HCC827; PC9
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DDR1
Associated microRNA: miR-199a-5p
Biological function: promotes proliferation, colony formation, migration and invasion; inhibits apoptosis
Molecular mechanism: circ_0087378 acts as a miRNA sponge for miR-199a-5p to facilitate DDR1 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

In NSCLC cell lines, circ_0087378 is highly expressed and mainly localized in the cytoplasm. circ_0087378 promotes malignant phenotypes (proliferation, colony formation, migration and invasion) and inhibits apoptosis by sponging miR-199a-5p, thereby relieving miR-199a-5p-mediated repression of DDR1.
Confidence score:

0.6585
Other information
Title:

Circ_0087378 intensifies the malignant behavior of non-small cell lung cancer cells in vitro by facilitating DDR1 via sponging miR-199a-5p.

Journal: Translational lung cancer research
Published: 2023
PubMed ID: 37197635
Study type:

biological research
Data availability: Available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-23-88/dss
Code availability: -