circRNA basic information
circBase ID: hsa_circ_0065173
Name: hsa_circ_SETD2
Synonym: circRNA SET domain containing 2 / circSETD2
Host Gene: SETD2
Genomic location(hg19): chr3:47155365-47168153:-
Genomic location(hg38): chr3:47113875-47126663:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005344
MONDO name: hepatitis B virus infection
Disease details: hepatitis B virus infection / HBV infection
Disease DO ID:
 2043
Disease MeSH ID:
 D006509
Disease NCIt ID:
 C3097
Disease ICD11 ID:
 1718385802
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HepG2; Hep3B; HepG2.2.15; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: DDX3 / HBsAg / HBx
Associated microRNA: miR-181a-5p
Biological function: Suppresses HBV proliferation/viral load and inhibits autophagy in HBV-infected hepatic cells.
Molecular mechanism: HBx suppresses circSETD2; circSETD2 downregulates miR-181a-5p, relieving repression on DDX3, leading to decreased autophagy.
Biological pathway or process:

autophagy (inhibits); viral replication (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; ELISA; Western Blot; CCK8; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

In HBV-infected hepatic cell models, circSETD2 is down-regulated by HBV/HBx. Restoring circSETD2 suppresses HBV viral load and inhibits autophagy by sponging miR-181a-5p, thereby increasing DDX3 expression.
Confidence score:

0.5607
Other information
Title:

Circular RNA SETD2 (circSETD2) elevates DDX3 expression to inhibit autophagy in hepatitis B virus infection via targeting miR-181a-5p.

Journal: BMC infectious diseases
Published: 2026
PubMed ID: 41484997
Study type:

biological research
Data availability: The data generated during the current study are available with the manuscript.
Code availability: -