circRNA basic information
circBase ID: hsa_circ_0014717
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:156290629-156304709:-
Genomic location(hg38): chr1:156320838-156334918:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; matched adjacent nontumorous tissues; gastric juice
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Associated with tumor stage, distal metastasis, tissue CEA and CA19-9 expression; ROC AUC 0.696 for differentiating gastric cancer tissues from controls; stable in gastric juice and potentially usable as a biomarker for screening high-risk gastric cancer patients.
Description:

hsa_circ_0014717 is significantly down-regulated in gastric cancer tissues and is associated with clinicopathological factors (tumor stage, distal metastasis, tissue CEA and CA19-9). It can be detected stably in gastric juice and shows diagnostic potential in tissue (ROC AUC 0.696), suggesting utility as a biomarker for screening/high-risk stratification.
Confidence score:

0.6556
Other information
Title:

Global circular RNA expression profile of human gastric cancer and its clinical significance.

Journal: Cancer medicine
Published: 2017
PubMed ID: 28544609
Study type:

combined biological and clinical study
Data availability: GSE89143
Code availability: -