| Expression pattern: |
UP |
| Associated gene: |
BIRC5, Ago2 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth and metastasis in vivo |
| Molecular mechanism: |
circMYBL2 acts as a ceRNA (molecular sponge) for miR-195-5p to upregulate BIRC5 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Ovarian cancer patients with elevated circMYBL2 levels exhibited significantly reduced overall survival; circMYBL2 may serve as a novel diagnostic marker and a potential therapeutic target for ovarian cancer. |
| Description: |
circMYBL2 (hsa_circ_0060467), derived from MYBL2, is upregulated in ovarian cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes ovarian cancer cell proliferation, migration and invasion, and enhances tumor growth and metastasis in vivo by sponging miR-195-5p to de-repress BIRC5 (Survivin) in a ceRNA axis. High circMYBL2 expression is associated with reduced overall survival in ovarian cancer patients. |
| Confidence score: |
0.8769 |