circRNA basic information
circBase ID: -
Name: hsa_circ_FKBP8
Synonym: circFKBP8(5S,6)
Host Gene: FKBP8
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002009
MONDO name: major depressive disorder
Disease details: major depressive disorder / MDD
Disease DO ID:
 1470
Disease MeSH ID:
 D003865
Disease NCIt ID:
 C35094
Disease ICD11 ID:
 -
Disease OMIM ID:
 608516
Species: Human
Species details: Homo sapiens
Tissue specimen:

prelimbic cortex (PrL) brain tissue
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UN
Associated gene: cFKBP8, DRD3, AMPK, mTOR, ULK1
Associated microRNA: -
Biological function: promotes stress susceptibility and depressive-like behaviors in CUMS mice; inhibits neuronal autophagy in PrL neurons
Molecular mechanism: circRNA-encoded protein (cFKBP8) down-regulates DRD3 expression, leading to suppression of DRD3 downstream AMPK/mTOR/ULK1 autophagy signaling
Biological pathway or process:

autophagy (inhibits); AMPK (inhibits); AMPK/mTOR (inhibits)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; Western Blot; IF (Immunofluorescence); In Vivo Animal Model
Clinical significance:

This study may provide new targets and ideas for the diagnosis and treatment of MDD.
Description:

In a mouse CUMS model, circFKBP8(5S,6) promotes stress susceptibility via its encoded protein cFKBP8. Mechanistically, it reduces DRD3 expression and suppresses DRD3-associated AMPK/mTOR/ULK1 signaling, leading to decreased neuronal autophagy in the prelimbic cortex.
Confidence score:

0.4852
Other information
Title:

circFKBP8(5S,6)-encoded protein promotes stress susceptibility in mice by down-regulating dopamine D3 receptor expression and its downstream AMPK/mTOR/ULK1 autophagy signaling.

Journal: Genes & diseases
Published: 2026
PubMed ID: 41459113
Study type:

biological research
Data availability: GSE294128
Code availability: -