| Expression pattern: |
UP |
| Associated gene: |
MAPK8IP2, AGO2 |
| Associated microRNA: |
miR-665 |
| Biological function: |
promotes prostate cancer cell proliferation, migration, invasion, metastasis and tumor growth |
| Molecular mechanism: |
acts as a miRNA sponge for miR-665 to upregulate MAPK8IP2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA-seq; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
CircMAML3 may be a potential biomarker for prostate cancer diagnosis, treatment and prognosis. |
| Description: |
circMAML3 is up-regulated in prostate cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation and metastatic phenotypes by sponging miR-665, thereby upregulating MAPK8IP2; knockdown suppresses tumor growth in a PC3 xenograft model. |
| Confidence score: |
0.8726 |