circRNA basic information
circBase ID: hsa_circ_0009172
Name: hsa_circ_DNA2
Synonym: -
Host Gene: DNA2
Genomic location(hg19): chr10:70218860-70229920:-
Genomic location(hg38): chr10:68459103-68470163:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: rheumatoid arthritis / RA
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker potential; negatively associated with anti-CCP antibody titers.
Molecular mechanism: Not specified.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Expression negatively associated with anti-CCP antibody titers.
Description:

hsa_circ_0009172 (derived from DNA2) is up-regulated in RA PBMCs and has diagnostic potential. Clinically, higher levels are associated with lower anti-CCP antibody titers; no direct downstream mechanism was validated in RA in this paper.
Confidence score:

0.4679
Other information
Title:

Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.

Journal: Journal of inflammation research
Published: 2025
PubMed ID: 41426249
Study type:

combined biological and clinical study
Data availability: Available on request from the corresponding author.
Code availability: -