| Expression pattern: |
DN |
| Associated gene: |
RGMB |
| Associated microRNA: |
miR-300 |
| Biological function: |
Circ_0000419 acts as a tumor suppressor in gastric cancer by inhibiting GC cell migration, invasion, glycolysis and in vivo tumor growth. |
| Molecular mechanism: |
Circ_0000419 sponges miR-300 and upregulates RGMB expression, thereby inhibiting migration, invasion and glycolysis in GC cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); glycolysis (inhibits); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_0000419 may be a molecular target for GC treatment. |
| Description: |
In this study, circ_0000419 was downregulated in gastric cancer tissues and cell lines. Its overexpression suppressed GC cell migration, invasion, glycolysis and xenograft tumor growth by acting as a sponge for miR-300 and upregulating RGMB, suggesting a tumor-suppressive role and potential therapeutic relevance. |
| Confidence score: |
0.7032 |