| Expression pattern: |
DN |
| Associated gene: |
SOCS3 |
| Associated microRNA: |
miR-668-3p |
| Biological function: |
promotes apoptosis; suppresses proliferation; suppresses migration; suppresses invasion; suppresses EMT; suppresses tumor growth |
| Molecular mechanism: |
ceRNA sponging of miR-668-3p leading to derepression of SOCS3 |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); TUNEL; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circ_0003356 expression was positively related to GC patient prognosis; Patients with low circ_0003356 expression correlated with a short survival time. |
| Description: |
circ_0003356 is down-regulated in gastric cancer tissues and cells and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits GC proliferation, migration, invasion, EMT while promoting apoptosis by sponging miR-668-3p to upregulate SOCS3. Higher circ_0003356 expression is associated with better patient survival. |
| Confidence score: |
0.823 |