| Expression pattern: |
UP |
| Associated gene: |
MAPK8, MAP3K1, KRAS, RASGRP1, SOS2, MAPK signaling pathway |
| Associated microRNA: |
hsa-miR-548aj-3p |
| Biological function: |
Promotes proliferation, migration, and invasion; inhibits apoptosis in breast cancer cells |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for hsa-miR-548aj-3p, regulating MAPK8 and MAP3K1 and activating MAPK signaling |
| Biological pathway or process: |
MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
Potential prognostic biomarker and therapeutic target for BC patients |
| Description: |
In breast cancer, hsa_circ_0001314 is up-regulated in tissues and cell lines. Its knockdown suppresses proliferation, migration and invasion while promoting apoptosis. Mechanistically, it acts as a ceRNA sponging hsa-miR-548aj-3p to increase MAPK8/MAP3K1 and activate MAPK signaling, suggesting biomarker/therapeutic potential. |
| Confidence score: |
0.6093 |