circRNA basic information
circBase ID: hsa_circ_0001030
Name: hsa_circ_EXOC6B
Synonym: hsa-circ-0001030
Host Gene: EXOC6B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000500
MONDO name: tongue squamous cell carcinoma
Disease details: tongue squamous cell carcinoma / TSCC
Disease DO ID:
 0050865
Disease MeSH ID:
 -
Disease NCIt ID:
 C4648
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TSCC tissues; adjacent normal tissues
Cell lines:

NOK; Cal27; SCC9; Tca8113; OSCC3; HSC6; Cal33; Ca727R; SCC9R; Tca8113R
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: PKM2
Associated microRNA: -
Biological function: Suppresses proliferation, migration, invasion, tumor growth/metastasis, aerobic glycolysis, and cisplatin resistance; enhances cisplatin sensitivity.
Molecular mechanism: Directly binds PKM2 (138-169 nt), inhibits PKM2 enzymatic activity, restrains tetramer formation, increases PKM2 Tyr105 phosphorylation, thereby blocking PKM2-driven glycolysis.
Biological pathway or process:

glycolysis (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); chemoresistance (inhibits)
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; CCK8; Colony Formation Assay; Transwell Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Low hsa-circ-0001030 expression correlated with advanced tumor-node-metastasis stage, poor differentiation, and unsatisfying prognosis in TSCC patients.
Description:

In TSCC, hsa-circ-0001030 is down-regulated and acts as a tumor suppressor that reduces proliferation, migration/invasion, tumor growth/metastasis, and cisplatin resistance. It directly binds PKM2 (138-169 nt), inhibits PKM2 activity and tetramer formation, increases PKM2 Tyr105 phosphorylation, and suppresses glycolysis, thereby improving cisplatin sensitivity.
Confidence score:

0.8446
Other information
Title:

Circular RNA hsa-circ-0001030 suppresses proliferation and cisplatin tolerance in TSCC via interaction with PKM2.

Journal: Cancer drug resistance (Alhambra, Calif.)
Published: 2026
PubMed ID: 41668805
Study type:

combined biological and clinical study
Data availability: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request, due to institutional data privacy restrictions.
Code availability: -