| Expression pattern: |
UP |
| Associated gene: |
HOXD3 |
| Associated microRNA: |
miR-203, miR-339-3p |
| Biological function: |
promotes proliferation and migration; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponge of miR-203 leading to increased HOXD3 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (other); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Cell Cycle Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Enhanced circPVT1 expression was closely associated with poor prognosis of patients with HCC; associated with overall survival, lymph node metastasis and TNM stages |
| Description: |
circPVT1 is up-regulated in HCC tissues and cell lines and is associated with poor prognosis. It promotes HCC cell proliferation, cell-cycle progression and migration, and enhances xenograft tumor growth by sponging miR-203 to increase HOXD3 expression. |
| Confidence score: |
0.7412 |