| Expression pattern: |
UP |
| Associated gene: |
UPF1, SIRT6 mRNA, YTHDC1, m6A |
| Associated microRNA: |
- |
| Biological function: |
promotes migration, invasion, and proliferation; promotes tumor growth in vivo; promotes lipid metabolism/lipogenesis; promotes metastasis via downregulating SIRT6 |
| Molecular mechanism: |
circRANBP17 forms a complex with UPF1 and recruits SIRT6 mRNA, facilitating NMD-pathway-mediated degradation and reducing SIRT6 mRNA stability; circRANBP17 is m6A-modified and bound by YTHDC1 |
| Biological pathway or process: |
lipid metabolism (promotes); AKT (promotes); metastasis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); mRNA stability (inhibits); m6A modification (other); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); MeRIP / MeRIP-seq; RNA Pull-Down; Luciferase Reporter Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Northern Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circRANBP17 is up-regulated in LUAD cells and promotes migration/invasion/proliferation and tumor growth. Mechanistically, it binds UPF1 and recruits SIRT6 mRNA to enhance NMD-mediated degradation, reducing SIRT6 and thereby supporting lipogenesis/lipid metabolism and metastasis. |
| Confidence score: |
0.8201 |