| Expression pattern: |
DN |
| Associated gene: |
TRIM67, AGO2 |
| Associated microRNA: |
miR-766-5p |
| Biological function: |
inhibits proliferation; inhibits clone formation; inhibits glycolysis; promotes chemosensitivity |
| Molecular mechanism: |
ceRNA sponge mechanism via miR-766-5p to regulate TRIM67 and glycolysis/chemoresistance |
| Biological pathway or process: |
glycolysis (inhibits); proliferation (inhibits); ceRNA regulation (promotes); chemoresistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Western Blot |
| Clinical significance: |
Exosome-derived circ_0094343 is proposed as a diagnostic marker for chemotherapy-resistant CRC patients and a therapeutic intervention for overcoming resistance. |
| Description: |
circ_0094343 (circPTEN) is down-regulated in colorectal cancer tissues (including chemotherapy-resistant and metastatic samples). Exosome-delivered circ_0094343 suppresses CRC cell proliferation/clone formation and glycolysis and increases sensitivity to multiple chemotherapeutics by sponging miR-766-5p to derepress TRIM67 (circ_0094343/miR-766-5p/TRIM67 axis). |
| Confidence score: |
0.6996 |