| Expression pattern: |
UP |
| Associated gene: |
PDPK1 |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, invasion and glutaminolysis, and inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-545-3p to de-repress PDPK1 (ceRNA-like regulation), thereby regulating malignant phenotypes and glutamine metabolism. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
circ_0000376 expression was closely associated with lymph node metastasis, tumor-node-metastasis stage, and tumor size of NSCLC patients. |
| Description: |
circ_0000376 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes and glutamine metabolism. Mechanistically, it binds (sponges) miR-545-3p to increase PDPK1, and circ_0000376 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7892 |