| Expression pattern: |
UP |
| Associated gene: |
HK2, Ago2 |
| Associated microRNA: |
miR-873-5p |
| Biological function: |
promotes CRC cell proliferation, migration, invasion, and glycolysis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0045932 sponges miR-873-5p to up-regulate HK2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; MTT; EdU Staining; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Overall survival of CRC patients with low hsa_circ_0045932 expression was higher than that of patients with high expression |
| Description: |
hsa_circ_0045932 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, migration/invasion, and glycolysis) and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-873-5p, thereby de-repressing HK2. |
| Confidence score: |
0.7789 |