| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-138-5p, miR-135a-3p, miR-338-3p, miR-135b-5p, miR-135a-5p, miR-135a, miR-135b |
| Biological function: |
May be involved in the pathogenesis of IMN and has potential diagnostic/predictive value as a blood biomarker. |
| Molecular mechanism: |
Predicted ceRNA mechanism via circRNA-miRNA-mRNA network, with miR-135 family as major candidate interactors. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other); TGF-beta/SMAD (other); Ras (other); Wnt/beta-catenin (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_101319 is upregulated in peripheral blood of IMN patients and shows diagnostic value (AUROC=0.89; sensitivity 93.33%; specificity 70.00%). |
| Description: |
circ_101319 (hsa_circ_101319, derived from RBM23) is significantly upregulated in peripheral blood of IMN patients and shows good diagnostic performance (AUROC 0.89). Bioinformatics analyses predict it may act through a circRNA-miRNA-mRNA ceRNA network, prominently involving miR-135 family members. |
| Confidence score: |
0.6556 |