| Expression pattern: |
UP |
| Associated gene: |
TNRC6B, RISC, Ago2 |
| Associated microRNA: |
miR-3186-3p |
| Biological function: |
circABCC4 promotes LUAD cell proliferation, migration, invasion, and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circABCC4 functions as a ceRNA by sponging miR-3186-3p to upregulate TNRC6B expression in LUAD. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; TUNEL; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circABCC4 is likely to be a novel and efficient biomarker in research concerning LUAD treatment. |
| Description: |
circABCC4 is up-regulated in LUAD tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses LUAD cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. Mechanistically, circABCC4 functions as a cytoplasmic ceRNA by sponging miR-3186-3p to positively regulate TNRC6B expression. |
| Confidence score: |
0.8355 |