circRNA basic information
circBase ID: hsa_circ_0009910
Name: hsa_circ_MFN2
Synonym: circ9910
Host Gene: MFN2
Genomic location(hg19): chr1:12049221-12052747:+
Genomic location(hg38): chr1:11989164-11992690:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: Cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HeLa; HaCaT; HCerEpiC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: c-Met
Associated microRNA: miR-198
Biological function: promotes cell viability
Molecular mechanism: acts as a miRNA sponge (ceRNA) for miR-198 to increase c-Met expression
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; MTT
Clinical significance:

may be a promising biomarker for CC
Description:

In cervical cancer cell context (HeLa), hsa_circ_0009910 is up-regulated and promotes cell viability. Its knockdown increases miR-198 and decreases c-Met mRNA, supporting a ceRNA-like hsa_circ_0009910/miR-198/c-Met regulatory axis.
Confidence score:

0.4062
Other information
Title:

Hsa_circ_0009910 knockdown in HeLa cells increases miR‑198 expression levels and decreases c‑Met expression levels and cell viability.

Journal: Oncology letters
Published: 2025
PubMed ID: 39650233
Study type:

biological research
Data availability: GSE113696
Code availability: -