circRNA basic information
circBase ID: hsa_circ_0091580
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chrX:132826396-132888203:-
Genomic location(hg38): chrX:133692368-133754176:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissue samples; paired adjacent normal tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: AP3B1
Associated microRNA: miR-1179
Biological function: unknown
Molecular mechanism: ceRNA axis prediction: hsa_circ_0091580 sponges miR-1179 to regulate AP3B1.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

One of the five circRNA-miRNA-mRNA mechanistic axes correlating negatively with HCC prognosis (hsa_circ_0091580/miR-1179/AP3B1).
Description:

hsa_circ_0091580 was differentially expressed in HCC tissues and validated by qRT-PCR in a 34-patient cohort. The study predicted a ceRNA mechanistic axis hsa_circ_0091580/miR-1179/AP3B1 that was reported to correlate negatively with HCC prognosis, but the interactions were not experimentally validated beyond expression testing and bioinformatic prediction.
Confidence score:

0.4032
Other information
Title:

Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.

Journal: Scientific reports
Published: 2023
PubMed ID: 38086834
Study type:

combined biological and clinical study
Data availability: GSE242797
Code availability: -