circRNA basic information
circBase ID: hsa_circ_0002019
Name: hsa_circ_FOXRED1
Synonym: circ_0002019
Host Gene: FOXRED1
Genomic location(hg19): chr11:126142863-126143349:+
Genomic location(hg38): chr11:126272968-126273454:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; surrounding tissues; GC tissues; paratumor tissues; normal gastric mucosa tissues; metastatic GC tissues; non-metastatic GC tissue; tumor tissues; adjacent tissues
Cell lines:

HGC-27; MKN45; NCI-N87; AGS; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PTBP1, TNFAIP6 mRNA, TNFAIP6, p65
Associated microRNA: -
Biological function: Promotes gastric cancer cell proliferation, migration, invasion, EMT and tumor growth; circ_0002019 knockdown inhibits these malignant phenotypes.
Molecular mechanism: circ_0002019 recruits/binds PTBP1 to increase TNFAIP6 mRNA stability, thereby activating TNFAIP6/NF-kappaB signaling in gastric cancer.
Biological pathway or process:

NF-kappaB (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); mRNA stability (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis
Clinical significance:

circ_0002019 is elevated in gastric cancer tissues and cells, is higher in metastatic GC tissue than non-metastatic GC tissue, and may have therapeutic value in GC treatment.
Description:

hsa_circ_0002019 is up-regulated in gastric cancer tissues and cells and is associated with metastatic GC tissue. It promotes GC proliferation, migration, invasion, EMT and tumor growth by binding PTBP1, increasing TNFAIP6 mRNA stability, and activating TNFAIP6/NF-kappaB signaling. Silencing circ_0002019 suppresses malignant phenotypes in vitro and inhibits xenograft tumor growth in vivo.
Confidence score:

0.835
Other information
Title:

Hsa_circ_0002019 promotes cell proliferation, migration, and invasion by regulating TNFAIP6/NF-kappaB signaling in gastric cancer.

Journal: Genomics
Published: 2023
PubMed ID: 37201873
Study type:

combined biological and clinical study
Data availability: GSE152309; GSE83521; Supplementary data: https://doi.org/10.1016/j.ygeno.2023.110641
Code availability: -