circRNA basic information
circBase ID: -
Name: hsa_circ_ABCB10
Synonym: -
Host Gene: ABCB10
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005005
MONDO name: clear cell renal carcinoma
Disease details: clear cell renal cell carcinoma / ccRCC
Disease DO ID:
 4467
Disease MeSH ID:
 -
Disease NCIt ID:
 C4033
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paired adjacent tissue
Cell lines:

A498; Caki-2; Cal-54; ACHN; Hs891.T; HREC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes ccRCC cell proliferation; inhibits ccRCC cell apoptosis; promotes tumor progression
Molecular mechanism: circ-ABCB10 overexpression enhanced A498 cell proliferation and repressed apoptosis, with down-regulated C-Caspase 3 and elevated Bcl-2; circ-ABCB10 knockdown showed opposite effects
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

high expression correlated with advanced pathological grade and TNM stage and independently predicted worse overall survival in ccRCC patients
Description:

circ-ABCB10 is up-regulated in ccRCC cell lines and tumor tissues. Functionally, it promotes A498 cell proliferation and inhibits apoptosis, accompanied by changes in C-Caspase 3 and Bcl-2. Clinically, high tumor tissue circ-ABCB10 expression correlates with advanced pathological grade, higher TNM stage, and worse overall survival.
Confidence score:

0.7169
Other information
Title:

Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma.

Journal: The International journal of biological markers
Published: 2019
PubMed ID: 31106654
Study type:

combined biological and clinical study
Data availability: Supplemental material for this article is available online.
Code availability: -