| Expression pattern: |
UP |
| Associated gene: |
MYO6, E-cadherin, Vimentin, Ki67 |
| Associated microRNA: |
miR-802 |
| Biological function: |
Circ_0076977 promotes OSCC cell proliferation, angiogenesis, migration, invasion, epithelial-mesenchymal transition, and xenograft tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0076977 functions as a ceRNA by absorbing miR-802, thereby up-regulating MYO6 expression in OSCC cells. |
| Biological pathway or process: |
proliferation (promotes); angiogenesis (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Circ_0076977 was up-regulated in OSCC tissues, and high circ_0076977 expression contributed to OSCC progression by targeting the miR-802/MYO6 axis. |
| Description: |
Circ_0076977 is up-regulated in OSCC tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, angiogenesis, migration, invasion, EMT, and xenograft growth while inducing apoptosis. Mechanistically, circ_0076977 sponges miR-802 to positively regulate MYO6 expression, promoting OSCC progression through the circ_0076977/miR-802/MYO6 axis. |
| Confidence score: |
0.7375 |