circRNA basic information
circBase ID: hsa_circ_0006156
Name: hsa_circ_FNDC3B
Synonym: -
Host Gene: FNDC3B
Genomic location(hg19): chr3:171965322-171969331:+
Genomic location(hg38): chr3:172247532-172251541:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent unaffected thyroid tissue; serum exosomes
Cell lines:

K1; IHH-4; BCPAP; TPC-1; Nthy-ori 3-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TLR4, AGO2
Associated microRNA: miR-1178 / miR-1178-3p
Biological function: promotes proliferation, migration, and invasion; inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: Acts as a ceRNA (miRNA sponge) for miR-1178 to upregulate TLR4
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; ROC Analysis
Clinical significance:

Diagnostic value in PTC tissues (AUC=0.891) and upregulated in serum exosomes from PTC patients; high expression associated with clinicopathological characteristics and shorter overall survival
Description:

circFNDC3B (hsa_circ_0006156), derived from FNDC3B, is up-regulated in PTC tissues, PTC cell lines, and patient serum exosomes. Functionally it promotes proliferation, migration/invasion, cell-cycle progression and tumor growth while inhibiting apoptosis. Mechanistically it acts as a ceRNA sponge for miR-1178/miR-1178-3p, thereby relieving repression of TLR4 and promoting PTC progression.
Confidence score:

0.8718
Other information
Title:

Circular RNA Profiling Reveals Exosomal circ_0006156 as a Novel Biomarker in Papillary Thyroid Cancer.

Journal: Molecular therapy. Nucleic acids
Published: 2020
PubMed ID: 32059339
Study type:

combined biological and clinical study
Data availability: GEO: GSE93522; https://doi.org/10.1016/j.omtn.2019.12.025
Code availability: -