circRNA basic information
circBase ID: hsa_circ_0008360
Name: hsa_circ_XPNPEP3
Synonym: circXPNPEP3
Host Gene: XPNPEP3
Genomic location(hg19): chr22:41277773-41278181:+
Genomic location(hg38): chr22:40881769-40882177:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: Diabetic nephropathy / DN
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

DN tissues; renal tissues; serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4, CREB5, ZFP36L1, GRAMD1B, PROM1
Associated microRNA: hsa-miR-135b-5p, hsa-miR-135a-3p, hsa-miR-1237-3p
Biological function: Potentially participates in DN progression as a miRNA sponge and may contribute to extracellular matrix accumulation, impaired angiogenesis, and disrupted cholesterol homeostasis.
Molecular mechanism: Predicted ceRNA mechanism: circXPNPEP3 may sponge hsa-miR-135b-5p/hsa-miR-135a-3p/hsa-miR-1237-3p to affect downstream mRNAs (e.g., SOX4, CREB5, ZFP36L1, GRAMD1B, PROM1).
Biological pathway or process:

ceRNA regulation (other); angiogenesis (other); lipid metabolism (other); fibrosis (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Serum circXPNPEP3 distinguished patients with DN from controls (AUC 0.8389; sensitivity 70.59%; specificity 86.27%), suggesting it as a non-invasive diagnostic biomarker.
Description:

circXPNPEP3 (hsa_circ_0008360), derived from XPNPEP3, is up-regulated in DN kidney tissues and patient serum and shows diagnostic potential (ROC AUC 0.8389). A bioinformatically predicted ceRNA network suggests it may sponge hsa-miR-135b-5p/hsa-miR-135a-3p/hsa-miR-1237-3p and thereby affect downstream genes such as SOX4, CREB5, ZFP36L1, GRAMD1B, and PROM1, potentially contributing to DN progression.
Confidence score:

0.459
Other information
Title:

Diagnostic Roles of circXPNPEP3 as Biomarker for Diabetic Nephropathy.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy
Published: 2025
PubMed ID: 41280375
Study type:

combined biological and clinical study
Data availability: GSE51674; GSE166239; GSE131882
Code availability: -