| Expression pattern: |
UP |
| Associated gene: |
SPRY4, p38 MAPK signaling pathway |
| Associated microRNA: |
miR-4516 |
| Biological function: |
circPFKP inhibits PTC cell proliferation, colony formation, migration, and invasion under baseline conditions, but protects PTC cells from stress- or radiation-induced apoptosis through the SPRY4/p38 MAPK pathway. |
| Molecular mechanism: |
circPFKP functions as a cytoplasmic ceRNA sponge for miR-4516, thereby relieving miR-4516-mediated repression of SPRY4 and regulating p38 MAPK signaling. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (inhibits); radioresistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circPFKP is significantly upregulated in PTC tissues and is highlighted as a potential novel therapeutic target for PTC patients. |
| Description: |
circPFKP is an upregulated circRNA in PTC derived from PFKP exons 18 and 19. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-4516 to upregulate SPRY4, thereby modulating p38 MAPK signaling. Functionally, circPFKP suppresses proliferation, migration, invasion, and tumorigenicity under baseline conditions, but it also reduces apoptosis under stress or irradiation, suggesting a dual role and therapeutic relevance in PTC. |
| Confidence score: |
0.7898 |