| Expression pattern: |
UP |
| Associated gene: |
SDC3 |
| Associated microRNA: |
miR-510-5p |
| Biological function: |
Circ-SCARB1 acts as an oncogenic regulator in RCC cells; its knockdown inhibits cell proliferation, migration and invasion, and induces apoptosis. |
| Molecular mechanism: |
Circ-SCARB1 functions as a miR-510-5p sponge and up-regulates SDC3 expression through the Circ-SCARB1/miR-510-5p/SDC3 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
Circ-SCARB1 is indicated as a potential therapeutic target for RCC. |
| Description: |
Circ-SCARB1 is up-regulated in RCC tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, it sponges miR-510-5p to relieve repression of SDC3, thereby promoting proliferation, migration and invasion while suppressing apoptosis in RCC cells. |
| Confidence score: |
0.7164 |