| Expression pattern: |
UP |
| Associated gene: |
CD44, CDH1 |
| Associated microRNA: |
miR-942, miR-510 |
| Biological function: |
Aggravates recurrence risk after ESD in EGC; suppresses miR-942/miR-510 and increases CD44 and CDH1 expression. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-942 and miR-510, thereby regulating CD44 and CDH1 (ceRNA-like regulation). |
| Biological pathway or process: |
ceRNA regulation (promotes); recurrence (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher circFNDC3B expression is associated with lower recurrence-free rate and may predict recurrence risk after ESD in EGC patients. |
| Description: |
circFNDC3B is upregulated in the high-expression EGC patient group after ESD and is associated with a lower recurrence-free rate. Mechanistically, it sponges miR-942 and miR-510 to increase CD44 and CDH1 expression, supporting its potential use as a recurrence-risk biomarker. |
| Confidence score: |
0.7083 |