| Expression pattern: |
UP |
| Associated gene: |
HMGB1, Ago2 |
| Associated microRNA: |
miR-1248 |
| Biological function: |
promotes EMT-mediated cell migration and invasion, induces lung metastasis, enhances cisplatin/DDP resistance, and reduces DDP-induced apoptosis in cervical cancer |
| Molecular mechanism: |
circ_0001589 acts as a ceRNA to sponge miR-1248, relieving miR-1248-mediated repression of HMGB1 3′-UTR and increasing HMGB1 protein expression |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0001589/miR-1248/HMGB1 axis has potential as a new therapeutic target against cervical cancer, including sensitizing cells to DDP treatment and inhibiting invasion/metastasis |
| Description: |
circ_0001589 is up-regulated in cervical cancer tissues and cell lines. It promotes EMT-mediated migration, invasion, lung metastasis, and cisplatin/DDP resistance by acting as a ceRNA for miR-1248 and increasing HMGB1 expression. Knockdown of circ_0001589 sensitizes cervical cancer cells to DDP and suppresses malignant phenotypes, supporting its potential as a therapeutic target. |
| Confidence score: |
0.8519 |