circRNA basic information
circBase ID: -
Name: hsa_circ_SETDB1
Synonym: hsa_circ_006352
Host Gene: SETDB1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005211
MONDO name: ovarian serous adenocarcinoma
Disease details: high-grade serous ovarian cancer
Disease DO ID:
 0050933, 5744
Disease MeSH ID:
 -
Disease NCIt ID:
 C7550
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: associated with SOC progression, lymph node metastasis, primary chemoresistance, and shorter progression-free survival
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Serum circSETDB1 distinguishes SOC patients from healthy controls and primary chemoresistant from chemosensitive patients; higher circSETDB1 correlates with advanced FIGO stage, lymph node metastasis, and shorter progression-free survival.
Description:

Serum circSETDB1 (hsa_circ_006352, host gene SETDB1) is up-regulated in high-grade serous ovarian cancer and is higher in primary chemoresistant than chemosensitive patients. High serum circSETDB1 is associated with advanced FIGO stage, lymph node metastasis, and shorter progression-free survival, supporting its value as a non-invasive biomarker for diagnosis and treatment-response/relapse prediction.
Confidence score:

0.4758
Other information
Title:

Serum circSETDB1 is a promising biomarker for predicting response to platinum-taxane-combined chemotherapy and relapse in high-grade serous ovarian cancer.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31686850
Study type:

clinical study
Data availability: -
Code availability: -