| Expression pattern: |
UP |
| Associated gene: |
UHRF1BP1L, UHRF1BP1L mRNA, UHRF1BP1L protein |
| Associated microRNA: |
miR-4693-3p |
| Biological function: |
Promotes malignant phenotypes of CRC cells, including cell proliferation and colony formation, inhibits apoptosis, and supports cell cycle progression; its up-regulation is associated with CRC occurrence and lymph node metastasis. |
| Molecular mechanism: |
hsa_circ_0005939 functions as a ceRNA by sponging miR-4693-3p, thereby enhancing UHRF1BP1L expression in CRC cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Up-regulation of hsa_circ_0005939 was associated with CRC occurrence and the number of lymph node metastases, and it may be a promising biomarker and therapeutic target for CRC. |
| Description: |
hsa_circ_0005939 is up-regulated in colorectal cancer tissues and cells. It promotes CRC malignant phenotypes by enhancing proliferation and cell cycle progression and inhibiting apoptosis. Mechanistically, it mainly functions as a cytoplasmic ceRNA that sponges miR-4693-3p to increase UHRF1BP1L expression, suggesting potential clinical value as a therapeutic target. |
| Confidence score: |
0.7534 |