circRNA basic information
circBase ID: hsa_circ_0001811
Name: hsa_circ_STAU2
Synonym: -
Host Gene: STAU2
Genomic location(hg19): chr8:74585341-74601048:-
Genomic location(hg38): chr8:73673106-73688813:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; matched non‐cancer tissues; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for gastric cancer based on decreased levels in tissues and plasma.
Molecular mechanism: Not specified (study focuses on expression and diagnostic value; no mechanistic experiments reported).
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Diagnostic value in gastric cancer tissues and plasma (AUC 0.658 in tissues, 0.747 in plasma; combined AUC 0.824). Lower levels correlate with clinicopathological indicators (e.g., CEA, CA19-9, lymph node metastasis, distant metastasis).
Description:

hsa_circ_0001811 is significantly down-regulated in gastric cancer tissues and in preoperative patient plasma. Its tissue and plasma levels show diagnostic utility by ROC analysis, and lower expression is associated with several clinicopathological features, supporting its potential as a non-invasive diagnostic biomarker.
Confidence score:

0.5958
Other information
Title:

Low expression of hsa_circ_0001811 in gastric cancer and its role in clinical diagnosis.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 33159345
Study type:

clinical study
Data availability: -
Code availability: -