circRNA basic information
circBase ID: hsa_circ_0017109
Name: -
Synonym: circ_0017109 / Circ-0017109
Host Gene: -
Genomic location(hg19): chr1:236192849-236201553:-
Genomic location(hg38): chr1:236029549-236038253:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor samples; non-carcinoma lung samples
Cell lines:

HBE; CALU3; CALU6; A549; H1229; H1299; H293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FZD4, beta-catenin, AGO2
Associated microRNA: miR-671-5p
Biological function: promotes proliferation and survival; inhibits apoptosis; promotes tumorigenesis
Molecular mechanism: ceRNA (miRNA sponge) mechanism: circ_0017109 sponges miR-671-5p to increase FZD4 and activate Wnt/beta-catenin signaling
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High level of circ_0017109 expression was associated with an worse overall survival among NSCLC cases; potential prognostic biomarker in NSCLC.
Description:

hsa_circ_0017109 is up-regulated in NSCLC tissues and cell lines and correlates with worse overall survival. Functionally, it promotes NSCLC proliferation and tumorigenesis and inhibits apoptosis by sponging miR-671-5p, thereby increasing FZD4 and activating Wnt/beta-catenin signaling.
Confidence score:

0.8396
Other information
Title:

CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/beta-catenin signaling due to modulating miR-671-5p/FZD4 axis.

Journal: BMC pulmonary medicine
Published: 2022
PubMed ID: 36434577
Study type:

combined biological and clinical study
Data availability: GSE101586; GSE112214; supplementary material available at 10.1186/s12890-022-02209-2; data-sets available from the corresponding author upon reasonable request
Code availability: -