circRNA basic information
circBase ID: hsa_circ_0006633
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:59805629-59844509:+
Genomic location(hg38): chr1:59339957-59378837:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent non-tumorous tissues; human healthy gastric mucosa; gastritis mucosa; gastric dysplasia tissues; plasma
Cell lines:

GES-1; HGC-27; SGC-7901; MGC-803; AGS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: May play an important role in gastric carcinogenesis and gastric cancer occurrence; low expression is associated with distal metastasis and tissue CEA level; may serve as a potential biomarker for screening gastric cancer.
Molecular mechanism: -
Biological pathway or process:

metastasis (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; divergent primers PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; IHC (Immunohistochemistry); ROC Analysis
Clinical significance:

Low expression was associated with distal metastasis and tissue CEA level; tissue ROC AUC was 0.741; plasma levels were significantly increased in gastric cancer patients, suggesting potential as a screening biomarker.
Description:

This study identifies hsa_circ_0006633 as a dysregulated circRNA in gastric cancer: it is downregulated in gastric cancer tissues and cell lines but increased in plasma from gastric cancer patients. Low tissue expression is associated with distal metastasis and tissue CEA level, and the authors propose hsa_circ_0006633 as a potential biomarker for gastric cancer screening.
Confidence score:

0.6663
Other information
Title:

Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Published: 2017
PubMed ID: 28656881
Study type:

combined biological and clinical study
Data availability: GSE89143; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89143
Code availability: -