circRNA basic information
circBase ID: hsa_circ_0007874
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:74175931-74176329:+
Genomic location(hg38): chr6:73466208-73466606:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

human HCC tissues; para-tumorous tissues
Cell lines:

Bel7402; HepG2; HEK293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NUDT21, CDX2
Associated microRNA: miR-9
Biological function: Overexpression of hsa_circ_0007874 antagonized miR-9-mediated silencing of CDX2 and rescued NUDT21 knockdown-induced HCC cell proliferation and colony formation.
Molecular mechanism: NUDT21 promotes hsa_circ_0007874 cyclization through UGUA motifs; hsa_circ_0007874 functions as a ceRNA sponge for miR-9 to restore CDX2 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (inhibits)
Detected method:
Q
B
S
M
Validation methods:

Microarray; RNA-seq; RT-qPCR; Northern Blot; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); MTT; Colony Formation Assay
Clinical significance:

-
Description:

hsa_circ_0007874 is a NUDT21 target circRNA downregulated in HCC-related datasets and NUDT21-knockdown HCC cells. It acts as a ceRNA for miR-9 to relieve repression of CDX2, and its overexpression suppresses NUDT21 knockdown-induced HCC cell growth and colony formation.
Confidence score:

0.623
Other information
Title:

NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma.

Journal: Oncogene
Published: 2020
PubMed ID: 31570791
Study type:

combined bioinformatics and biological research
Data availability: GSE94508; GSE14520; Supplementary Table 1; Supplementary Table 2; Supplementary Table 3; Supplementary Table 4
Code availability: -