circRNA basic information
circBase ID: hsa_circ_0001847
Name: hsa_circ_UBAP2
Synonym: circUBAP2(9,12) / circUBAP2 (9,12)
Host Gene: UBAP2
Genomic location(hg19): chr9:33953282-33963789:-
Genomic location(hg38): chr9:33953284-33963791:-
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma / NPC
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NPC tissues; nasopharyngitis samples; adjacent normal epithelial tissues; histologically normal surgical margins
Cell lines:

HNE2; CNE2; HK1; NP69; SUNE1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: AUF1, ZEB2 mRNA
Associated microRNA: -
Biological function: Suppresses NPC cell migration, invasion, and metastasis; inhibits EMT
Molecular mechanism: circUBAP2(9,12) acts as an AUF1-binding decoy to reduce AUF1-ZEB2 mRNA interaction, decreasing ZEB2 mRNA stability and suppressing EMT
Biological pathway or process:

migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); mRNA stability (inhibits)
Detected method:
Q
H
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); Survival Analysis; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study
Clinical significance:

Low circUBAP2(9,12) expression was associated with unfavorable prognosis and shorter overall survival in NPC patients
Description:

circUBAP2(9,12) (hsa_circ_0001847), derived from UBAP2 exons 9-12, is down-regulated in nasopharyngeal carcinoma and low expression predicts poorer survival. It suppresses NPC migration/invasion/metastasis by binding the RBP AUF1 and competitively reducing AUF1 binding to ZEB2 mRNA, thereby decreasing ZEB2 mRNA stability and inhibiting EMT.
Confidence score:

0.8986
Other information
Title:

CircUBAP2(9,12) Inhibits Nasopharyngeal Carcinoma Invasion and Metastasis by Down-regulating ZEB2 through Competitive Binding to AUF1.

Journal: Research (Washington, D.C.)
Published: 2025
PubMed ID: 41194937
Study type:

combined biological and clinical study
Data availability: GSE181906
Code availability: -