| Expression pattern: |
DN |
| Associated gene: |
CDH1, E-cadherin |
| Associated microRNA: |
miR-296-3p |
| Biological function: |
Potentially acts as a ceRNA/miRNA sponge in BKPyV infection; proposed to influence epithelial integrity via E-cadherin regulation and thus may contribute to BKPyV pathogenesis; may serve as a non-invasive diagnostic biomarker. |
| Molecular mechanism: |
ceRNA mechanism: decreased circ-AKT3 reduces miRNA sequestration, allowing miR-296-3p to accumulate and repress CDH1 (E-cadherin). |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC curve analysis demonstrated that these circRNAs could significantly differentiate BKPyV-infected individuals from non-infected groups. |
| Description: |
circ-AKT3 is down-regulated in blood and urine of BKPyV-infected kidney transplant recipients and shows a negative correlation with miR-296-3p. The study supports a putative ceRNA axis in which reduced circ-AKT3 may permit increased miR-296-3p activity and contribute to repression of CDH1 (E-cadherin), with potential utility as a diagnostic biomarker for active BKPyV infection. |
| Confidence score: |
0.559 |