circRNA basic information
circBase ID: -
Name: hsa_circ_ASAP1
Synonym: ASAP1-12100-A5BS
Host Gene: ASAP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BM36 brain region
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SNCA, APOE, PSEN1
Associated microRNA: miR-455-3p
Biological function: associated with AD progression; depletion may release miR-455-3p and enhance its activity
Molecular mechanism: Predicted miRNA sponging/release mechanism along severity: progressive downregulation releases miR-455-3p, enhancing miR-455-3p activity and downregulating its targets
Biological pathway or process:

ceRNA regulation (inhibits); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

correlates with AD progression/severity (consistent depletion with increased AD severity)
Description:

ASAP1-12100-A5BS shows progressive depletion with increasing AD severity in BM36. It is predicted to bind miR-455-3p, and its downregulation is associated with enhanced miR-455-3p activity and downstream suppression of miR-455-3p target genes, suggesting a role in AD progression.
Confidence score:

0.1768
Other information
Title:

Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.

Journal: Communications biology
Published: 2024
PubMed ID: 39427093
Study type:

bioinformatics study
Data availability: ENCODE database (Experiment IDs in Supplementary Data 1); Synapse SynID: syn3159438; Supplementary Data 4
Code availability: https://github.com/lichen-lab/circMeta2