circRNA basic information
circBase ID: hsa_circ_0000591
Name: hsa_circ_MGA
Synonym: circMGA
Host Gene: MGA
Genomic location(hg19): chr15:41961025-41962156:+
Genomic location(hg38): chr15:41668827-41669958:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps; cortex; brainstem
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR
Clinical significance:

-
Description:

circMGA is among the circRNAs identified as particularly altered in ALS in this study, contributing to the broader pattern of CNS downregulation and tissue-dependent circRNA deregulation.
Confidence score:

0.385
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

combined biological and clinical study
Data availability: GSE289637
Code availability: -