circRNA basic information
circBase ID: hsa_circ_0005051
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:196118683-196120490:-
Genomic location(hg38): chr3:196391812-196393619:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; paracancerous tissues; plasma; peripheral blood
Cell lines:

GES1; MGC-803; BGC-823
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Predicted ceRNA network for hsa_circ_0005051 (not experimentally validated).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Plasma hsa_circ_0005051 is downregulated in GC; ROC AUC 0.73 for distinguishing GC from controls; contributes to dual-circRNA diagnostic signature, but shows no significant preoperative vs postoperative difference.
Description:

hsa_circ_0005051 is down-regulated in gastric cancer tissues/cells/plasma and provides diagnostic value in plasma (AUC 0.73) as part of a dual-circRNA signature with hsa_circ_0021087. Its preoperative versus postoperative plasma levels do not show a significant difference, and its mechanistic role is only presented as a predicted ceRNA network.
Confidence score:

0.5047
Other information
Title:

A Dual-Circular RNA Signature as a Non-invasive Diagnostic Biomarker for Gastric Cancer.

Journal: Frontiers in oncology
Published: 2020
PubMed ID: 32154178
Study type:

combined biological and clinical study
Data availability: GSE83521; GSE89143; GSE93541; https://cancergenome.nih.gov/
Code availability: -