circRNA basic information
circBase ID: -
Name: hsa_circ_MGA
Synonym: circMGA
Host Gene: MGA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer / BCa
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: CD8+T cells
Associated microRNA: -
Biological function: tumor-suppressing properties and functions as a chemoattractant for CD8+T cells
Molecular mechanism: chemoattractant for CD8+T cells
Biological pathway or process:

immune regulation (promotes)
Detected method:
S
Validation methods:

RNA-seq; Survival Analysis; Bioinformatics Analysis
Clinical significance:

heightened levels of circMGA were associated with a favorable prognosis; increased circMGA expression predicts improved OS in early-stage tumors received immunotherapy
Description:

In a large BLCA immunotherapy cohort analyzed in TCCIA, higher circMGA levels are associated with favorable prognosis, and in early-stage tumors receiving immunotherapy it strongly predicts improved overall survival. Elevated circMGA expression is also associated with a higher CD8 T cell signature, consistent with an immune-attractant role.
Confidence score:

0.348
Other information
Title:

TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy.

Journal: Journal for immunotherapy of cancer
Published: 2024
PubMed ID: 38212124
Study type:

bioinformatics study
Data availability: Zenodo (https://zenodo.org/doi/10.5281/zenodo.7969298)
Code availability: https://github.com/ShixiangWang/circrna-pipeline