| Expression pattern: |
UP |
| Associated gene: |
Cyclophilin B, CypB, Jak2, p-Stat3, JAK2, p-STAT3, MYC |
| Associated microRNA: |
miR-206 |
| Biological function: |
circTCF25 promotes glioma cell proliferation, migration, invasion, metastasis, tumorigenesis and tumor growth, and inhibits cell death. |
| Molecular mechanism: |
circTCF25 acts as a ceRNA/miRNA sponge for miR-206, positively regulating CypB expression and activating the JAK2/p-STAT3 signaling pathway. |
| Biological pathway or process: |
JAK/STAT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot |
| Clinical significance: |
High circTCF25 expression was associated with advanced clinical grade and poor prognosis; it may serve as a prognostic marker and treatment target for glioma. |
| Description: |
circTCF25/hsa_circ_0041103 is up-regulated in glioma and high expression is associated with advanced grade and poor overall survival. Mechanistically, it functions as a cytoplasmic miR-206 sponge to increase CypB expression and activate the JAK2/p-STAT3 signaling pathway, thereby promoting glioma proliferation, migration, invasion, metastasis and tumorigenesis. |
| Confidence score: |
0.784 |