circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: circCCDC66
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; normal tissues
Cell lines:

A549; H1299
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: SRCIN1
Associated microRNA: miR-211
Biological function: promotes NSCLC cell proliferation
Molecular mechanism: ceRNA/miRNA sponge: circCCDC66 sponges miR-211 to regulate SRCIN1 expression
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Luciferase Reporter Assay; CCK8
Clinical significance:

circCCDC66 ... might act as a potential diagnostic biomarker for NSCLC
Description:

circCCDC66 promotes NSCLC cell proliferation in vitro. Mechanistically, it acts as a ceRNA/miRNA sponge for miR-211, thereby relieving miR-211-mediated suppression of SRCIN1 and supporting the miR-211/SRCIN1 axis.
Confidence score:

0.4712
Other information
Title:

SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.

Journal: BioMed research international
Published: 2020
PubMed ID: 32964035
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -