| Expression pattern: |
UP |
| Associated gene: |
MECP2 |
| Associated microRNA: |
miR-193a-3p |
| Biological function: |
CircDHRS3 aggravates IL-1beta-induced chondrocyte ECM degradation, apoptosis, and inflammatory response, and represses chondrocyte proliferation in the osteoarthritis model. |
| Molecular mechanism: |
CircDHRS3 functions as a ceRNA/miRNA sponge for miR-193a-3p to increase MECP2 expression, thereby promoting IL-1beta-induced chondrocyte injury. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (promotes); proliferation (inhibits); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In this study, hsa_circ_0010024/circDHRS3 was up-regulated in osteoarthritis cartilage samples and IL-1beta-treated chondrocytes. CircDHRS3 promoted chondrocyte ECM degradation, apoptosis, and inflammatory response and inhibited proliferation by sponging miR-193a-3p to increase MECP2 expression. |
| Confidence score: |
0.6536 |